Cmon use your head for a second. Obviously no one wants to live arbitrarily longer. The goal of longevity research is not just to add years. It’s to improve lifespan AND healthspan. The goal is to make 80 feel like 30 or 40. The goal is to make 80 not suck; the only reason you think we live too long and more elderly is bad is because, with our current level of tech, it does legitimately suck to get old.

Methuselah lived 969 years according to the bible.

And from a scale of 1 to 10 how possible is it to reduce entropy in an open system?

Here is a hint, my air conditioner is running as I type this.

The heat death of the universe isn't a certainty because our cosmology theories are laughably incomplete.

That would require somehow outliving the heat death of the universe.

Wouldnt matter. If you lose the "a" neuron, you lose it forever. Each neuron that you swapped out would get an "empty", until you were all empty. At least that's probably what would happen - nobody really knows for sure, we don't go around doing stem cell replacements in you brain right now.

Maybe even literally forever eventually. We know nothing about the nature of consciousness yet, but we will at some point.

I used to follow longevity (broadly) but don't follow closely anymore since all the player's have been saying the same thing for the last decade. I don't have 3 hours to listen to this but curious about the state of play.

He's bullish on AI & cancer treatments. Seems reasonable that progress there would increase the average lifespan/healthspan but not necessarily extent beyond the current limits (~110 years). "Possibility of complete age reversal within 15 (years)" seems based on hope & dreams (and maybe more AI)?

Not if the replacement was done correctly.

But you wouldn't replace them all at once

I’ve heard this before lol

Agreed; looks like the author of this article was one "Emily S" who did their undergraduate degree in Journalism with a minor in music. I don't want to come across as an arrogant ass, but this is why it'd be nice if we have people who actually have a degree in the sciences to be writing these articles (or if these humanities majors would ask someone from the sciences for an opinion before going to the press).

What I find funny is this is also how we determine what is considered food safe or safe for people in general.

'Well our current data says this is fine.'

5 decades of data later

'Yeah don't get near that without PPE'

Oh dear god, no

If you tried to replace all the mutated cells, you would not just lose some event memory. You could potentially lose all of your memory. Like language. Math. And on top of that, advanced dementia like conditions. Very bad.

Some good timestamps:

• 00:02:16 - Why the next 10 years may add 50 to your lifespan
• 00:24:28 - Why AI may be medicine's greatest force multiplier
• 00:30:41 - Can AI replicate a scientist's biological intuition?
• 00:37:22 - Why ignoring AI may soon be considered malpractice
• 01:03:24 - Could most cancers become beatable within a decade?
• 01:29:56 - Can the body be engineered to resist aging?

Wouldn't you just kind of rotate memories?

I always assumed that someone living past 100 years would kind of start to rotate memories rather than keep accumulating. Which would mean that your personality is evolving, but whatever tail that you keep is sufficient for you to retain sane perception of who you are.

Have you hung out with any 100 year olds? Good bunch just nap a lot. 

We live too long now. I’m taking care of 3 old people. Anything past 80 sucks or is going to any minute. More elderly is the last thing we need.

I try not to learn anything and that saves space on the hardrive. 

Sounds absolutely awful tbh

The author of the article doesn’t understand what they were writing about.

The 122 year lifespan estimate is based on the oldest recorded human in (low confidence) demographic data. The 156 year lifespan figure is examining one single component - ie somatic mutations - and describes what the life span limit would be if we were to fix everything else.

Those are completely different things.

I mean, becoming an Android sounds ideal.

You realize that our biliogical brains can't go on forever?? You will literally start running out of neurons, just like hardrive on your computer runs out of space. No matter what you do. So unless you are willing to live in fully android body there is no such thing as living forever, at least not with the brain you were born with....

Likely trying to model after the Bible which says we cap out at 120 years