I have ADHD and CPTSD, as well as poor sleep quality since adolescence. I've tried most sleep medications, including trazodone, mirtazapine, agomelatine, chlorprothixene, chlorpromazine, quetiapine, doxylamine, clonidine, zopiclone, lemborexant, gabapentin, diazepam, clonazepam, phenazepam, and alprazolam, as well as sleep hygiene and CBT for sleep.

However, the best medication that gives me that feeling of rest is clozapine at a dosage of 25mg-50mg. I use it no more than twice a week, the day before my ADHD medications holidays. The doctor told me that even infrequent use requires blood monitoring.

I can truly say that this is the best antipsychotic I've tried. Another interesting effect is that it has a positive effect on hyperactivity.

Of all the above, I've stick to lemborexant and clonidine. It's non-addictive and helps me fall asleep every day, although my sleep quality is still superficial on them.

I use chlorprothixene on days when I'm taking a stimulant, but it greatly increases hunger, leading me to eat frequently at night, which negatively impacts my figure. Interestingly, clozapine doesn't cause as much appetite, I don't wake up hungry when taking it.

Hello, I struggle with brain fog on my current antipsychotics. Is clozapine better for bringing clarity, or is it the same/worse than other antipsychotics? Thank you

I've started clozapine last week and decreased the amisulpride I used to take. My hallucinations are getting bad again because of that.

I was wondering if I could see symptoms decrease soon or have to wait a long time for that.

My psychiatrist doesn't want me on both of them to see if there are any benefits or I'll get too many side effects.

I’m kinda scared due to all the side effects and incessant labs, but hoping it works.

Does it really diminish your symptoms?

Ive being going on diets, walks, workouts but nothing is changing. My psychiatrist won’t lower the dose. So Im contemplating starting on ozempic , Im 25 years old .

Im on 200mg
Anyone else struggling with weight gain?

I am currently on 100 mg clozapine before bed. My doctor allowed disconuation. How long will withdrawal last?

Hi All,

Since January I am facing everyday afternoon dread waves in afternoon followed by overwhelming crying as release, I tried escitalopram didn’t help , tried desvenlaflaxine I reacted badly , now doctor wants to me to try paroxentine and clozapine .25, I feel heavily sedated drowsy not like myself I have been on it for 1 week, will it get better ? Dread waves anxiety attacks didn’t improve but I became zombie tha I didn’t cry yesterday, any inputs will be helpful

Question as title. THanks for any replies!

So clozapine immediately had an effect on my ability to do strenuous activity, climb hills, etc. and it hasn't gotten better 3 years in. I'm wondering if anyone has found a way to deal/mitigate this? Obv this is the only med that worked for my psychotic symptoms so going off it isn't an option.

Hey I’m dealing with bad insomnia and trouble falling and staying asleep. My dor told me to take 12.5 mg of clozapin for sleep.

What do you guys think about it?

Help!!!!

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i used as an off label drug for sleep I don't use big doses like 50mg and 25 mg , i divide my 25 mg tablet to 2 parts and take one part maximum it works great but makes me sleepy and very tired .

should i add something with clozapine to stop these nasty side effects or no because I can't tolerate these side effects and can't tolerate less sleep.

My sister had a relapse and is currently on 100mg clozapine. She's experiencing hallucinations (hearing voices) and delusions. Her doctor has recommended biweekly CBC tests. I wanted to ask - are there other things I should be keeping an eye on while she's on this medication? Any insights from personal experience would be appreciated.

I'm already on 600mg of clozapine a night and I still have low voices. I'm on both aristada and clozapine.

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The new Dr does not want to increase my clozapine dose. He said he'd rather switch the aristada because too much clozapine is dangerous.

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So his suggestion is clozapine and invega combo.

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What do you think?

what if clozapine does not help?

I'm hearing whispers but I'm still hearing voices. I can clearly make out what they are saying. My Np has been no help. I don't see the psychiatrist until 06/11. What should I do?

Were theier voices while you were waiting on it to get in your system? And how did your doctor titrate you up? Were there weekly doctors appointments? Phone call,? Specific instructions? What? Asking Because I'm going to be on it soon

If so how much weight did the other antipsychotics give you and how much did the clozapine give you?

I changed taking my 100mg clozapine from bedtime to 5pm because I have to wake up early in the mornings for work. I started this earlier this week. Yesterday I had a mild manic episode. I was completely aware of it but it was there. Could this have any relation to me taking the Clozapine now in the afternoon/ early evening vs at bedtime? If so, will my body adjust to the new time?

Hi. My doctor lowered my clozapine intake from 100mg to 75mg and I have trouble sleeping.

I didnt expect to have this problem titrating from 100mg to 75mg to be honest. Anyone had similar problem and how long this lasts?

My side effects include: constipation, weight gain, drooling at night, incontinence and I need 10-14 hours of sleep per night otherwise I feel very nauseous. But honestly the severe bloating I get is as bad as the weight gain... I feel like I'm pregnant and it's the reason I stopped doing yoga because it's a lot harder now. In terms of the weight gain, I gained 25kg in just the first 3 months 😞

On haldol 20 mg, cobenfy 125/30 and invega 12 mg. The current medication I'm on is not working and I know the voices will torture me if I come off any of it. I have to wait on the the clozapine to take affect and find the right dosage from a low dose. What do I do?