r/ResearchCompounds • u/Traditional-Yam6959 • 3d ago

Discussion Will Reta decrease running performance?

Hi, I’m a 20F looking to lose about 5 kg using retatrutide. I’m a long-distance runner and have completed multiple marathons, so running is a big part of my life, but I’m aiming to lean out slightly.

I took my first injection about a week ago and have already noticed a drop in my running performance, especially a slower pace. From what I understand, this can happen due to factors like increased heart rate, reduced calorie intake, and lower glycogen stores.

My question is whether this is just temporary while I’m on the medication, or if it could have longer-term effects. Once I stop retatrutide after a few months, is it likely that my performance will return to baseline or even improve, or could this dip in performance carry over?

Would really appreciate hearing from anyone with experience or insight on this.

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u/v0idl0gic 3d ago

The heart rate increase on Reta is problematic for some endurance athletes. For that reason if I was you I would consider Tirzepatide instead. It too can increase heart rate, but it's much more mild and more transient. So I guess, why are you thinking Reta and not Tirzepatide?

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u/SarahKH88 2d ago

Why does it raise heart rate?

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u/v0idl0gic 2d ago

Reta had a glucagon agonist and the heart has glucagon receptors.

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u/Traditional-Yam6959 3d ago

Because I can’t get hold of it in the country I live in, it’s quite strict here and haven’t found anyone with that trug here

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u/372xpg 3d ago

Where are you that you gave no problem getting reta an experimental peptide but not tirzepatide an approved peptide?

What is wrong with you? You are a high performing long distance runner. You want to take a drug to lose more weight. You are 20 and run marathons?! You are the exact opposite person that should be using reta or any glp peptide.

What you have is a mental illness called body dysmorphia, perhaps anorexia. Your body is likely in its most efficient place and you are not having any issues with poor signalling and overeating. The only outcome you are going to have is poor performance and damage to your health.