Hello all.

I've got insulin resistance and PMOS, and have tried a number of things to lose weight. I tried Mounjaro a while ago and experienced very horrendous side effects. I couldn't eat or drink, was extremely tired. and overall felt sick. It got so bad, I had to go to the hospital for medical treatment. This was only after the 1st dose, so the doctors felt that it would be unadvisable for me to continue with it.

So now, I'm back to square one with tracking every crumb that goes into my mouth and exercising regularly. The classics that should work, but just don't all that well. Despite my experience, I'm curious if a different GLP-1 could be a better option.

I've thought about trying the Rybelsus pill since it's cheapest, but I'm worried that it would make me feel equally as unwell as Mounjaro did. People say they have less side effects with the pill vs the injection, but people also said they experienced less side effects from tirzepatide vs semaglutide. I'll be speaking with my doctor about this but I'm curious what others with this condition have experienced.

I am in Japan, so I can't buy compounded GLP-1s. Thanks to anyone with some advice!

Tomorrow I pick up my first month of semaglutide. I'm scared. My insulin resistance is insane, my fasting level was 67. My HOMA-IR score is 15.2. I'm gaining weight no matter what type of eating I do or what nutrients I count, what defects I'm in. I have hirsutism and at the same time hair thinning on my head. I have a poor libido.

Metformin made me extremely ill and I'm not approved for phentermine because of POTS. GLP1 is looking like the only way out. I've seen it be the absolute lifesaver for many, but I'm scared that the GLP1 is going to make me lose what little hair I have left, and eliminate my libido entirely. I don't want to sacrifice the very last bits of my pride and who I am, or my intimate life with my husband.

Please tell me positive stories or give input based on your experience? :(

i was recently prescribed zepbound by my endocrinologist and was told that it was going to be $500/month because my insurance doesn’t cover. the next day, they instead prescribed me wegovy because my insurance covers it but now its $770/month!

i could barely afford the first option and theres no way i can afford the second. where are you guys finding affordable glp-1s? i’ve heard getting compounded versions or trying directly from manufacturers but this is my first time dealing with this stuff and i’m completely lost and overwhelmed

Decided I was going to try monjaro, why do I keep procrastinating ordering it.

​

I have an appointment with my gp next week to inform her of the insulin resistance test I had done and i keep thinking maybe I should wait until then.

But im also like.... Just order it now so I can start sooner

Hello everyone, my name is sugar vanilla and I have had three of my providers my primary care physician My Gyno and my cardiologist recommends me going on a GLP-1 to help lose weight with my insulin resistance that I have going on. I have chosen the Wegovy pill through Ro.
Is anyone else on Wegovy to help with weight loss and if so what does your typical day look like with like meals and side effects?.

Thank you

Hi guys!

I have mild insulin resistance and was prescribed Zepbound to lose weight. So far I've lost 60 pounds but now I've plateaud and it takes me weeks to drop in weight. It never happens gradually, one day I've just lost 5 pounds. Anyone else going through this? I'm on inositol too, no berberine.

I'm considering bringing this up to my endocrinologist to see if maybe a medication like Metformin will be appropriate. Just wanted to see if anyone was in a similar situation.

I have tried everything and decided to finally go on wegovy. I am nervous but looking forward to it!! what are things you wish people told you?

I have tried everything and decided to finally go on wegovy. I am nervous but looking forward to it. I am nervous of the face slagging/drolling to the weight is there anything that can help?

Recently had a private blood test confirming I have insulin resistance. I have an appointment to discuss this with my gp. Now its been confirmed and im already doing the diet and exercise recommended for it iv decided to see if wegovy or monjaro will help.

Should I wait until I see my gp before getting it or just start now?

I have to wait 3 weeks for the appointment, and as I'm UK based There is no chance I will get it on nhs in my area as they don't offer it.

Hi everyone, I’m a master’s student in Applied Psychology Mental Health, currently undertaking research for my dissertation on GLP-1 users’ experiences with food, lifestyle and mental health. I'd love to hear from people with PCOS/PMOS to get a more accurate representation of GLP-1 users.

Who can participate?

• aged 18+
• living in Ireland or the United Kingdom
• prescribed a GLP-1 medication, such as Ozempic, Wegovy, Mounjaro or Saxenda
• taking it for 3 months or longer

The survey is anonymous and takes approx 20 minutes.

If you’re eligible, you can take part here: 

https://ucc.qualtrics.com/jfe/form/SV_0ugHbdZHPtudDZs

The aim of the research is to better understand the day-to-day experiences of GLP-1 users, including food, eating patterns, lifestyle changes, wellbeing and mental health. This study is not funded and has no commercial interest.  More information about the study is provided on the first page of the survey.

This study has been approved by the University College Cork research ethics board.

Thank you so much to anyone who takes the time to complete it. Please feel free to ask any questions.

Hi everyone,

Ive been diagnosed with pmos/pcos for over 10 years and Ive been struggling a lot with my weight as most of us do. Ive been wondering what glp-1s ppl have tried and what's been working and what hasn't been working for you.

Ive been on ozempic and metformin and neither of those worked, and i was hoping to ask my doctor for something else to try but I wanted to find out a bit more what's helped with others

I’ve been deep in the binge cycle for a year and a half now. The last few months have been pretty bad and I regained a lot of the weight I lost a couple of months ago. I have PMOS but I feel most of my symptoms (fatigue, weight gain, skin changes, excess hair) stem from my binging. I went to the Drs today to tell my Dr about it in the hopes that I would be referred to a psychologist or something to tackle this from the root. Instead she immediately offered me the Wegovy injection which was something I hadn’t really thought about prior to the appointment, mainly because I didn’t consider it an option 😭 I brought up feeling really anxious lately but she kept going on about the Wegovy. Obviously it was my choice and I didn’t feel pressured to say yes but I was just nervous especially with there being so much discourse about GLP-1s. Anyway, I eventually got it and am just deciding what to do. I’m pretty desperate to get better and start living a healthier life but I was also hoping to do it all the “natural” way. Has anyone been in a similar situation? 🤎

I was diagnosed With PCOS two years ago and I feel no progress is being made in regards to weight loss through metformin and being more active and eating cleaner.

How can I get for doctor to prescribe GLP-1 so that my insurance covers it?

I have a gynecologist appointment in two weeks. Should I speak about it with them?

Any advice would be helpful.

I am moderately overweight with PCOS and low thyroid (that is controlled with medication) Was on Ozempic for a bit and it really worked in reducing food noise and my desire to eat was minimal. I have since moved to Zepbound. Did 3 weeks at 2.5 and now have done 2 injections at 5 with 2 more to go. I was on 1 of Ozempic so I skipped one 2.5 dose of Zepbound. I have had zero bad side effects of either, but also very minimal weight loss :( Is there a dose that worked for you? I heard these drugs have been a saving grace for PCOS and I am cautiously optimistic but also know they won’t work for everyone. Is there still hope? How did you feel at 7.5 or 10? Did that help? TIA

Hi!

I got diagnosed with PCOS/PMOS last November 2024. I’ve struggled with weight my whole life pretty much and once I got the diagnosis I started taking ozempic for almost a year and then switched to mounjaro once it stopped really being so effective. So far I’ve lost 57lbs (I’m F31 5’5 currently 151lbs) and am really happy with the overall progress.

I feel like I’ve come to a bit of a plateau and the mounjaro seems to no be as effective as it was (I’m on 10mg); I’m generally hovering around 148-152lbs for the last months. I walk a lot, and generally just try to eat intuitively (have seen dietitian’s in the past to help with disordered eating which was super helpful and useful, but this was pre PCOS diagnosis).

Anyway my question is how do I shift these last pounds? I want to get to around 135lbs, give or take. Has anyone experienced something similar and how did you overcome it? I’ve had bouts of running a lot in the past as well as weight training. I’ve just taken out my gym membership again to get back into strength training and will also start running a bit more now the weather is getting nicer.

Also open to advice re medication or anything else.

I was diagnosed with PMOS/PCOS about 2 years ago at 18 and last summer I saw a doctor about starting a GLP-1 to start losing weight. I got put on both Wegovy and Metformin and it was honestly the sickest I have ever been, I didn't go a week without throwing up due to it. It was semi effective in that I lost 30lbs over 6 months but that was mostly because I couldn't stomach food very well at all. I ended up going off both medications due to the side effects.

Unfortunately, in December I ended up getting emergency surgery to have my gallbladder removed since a gallstone had given me acute pancreatitis. Since then I've ended up gaining all the weight back and I think I will just keep gaining weight at this rate which is not ideal.

I'm thinking about starting some kind of GLP-1 and or Metformin again to manage this but I'm just wondering if anyone has had any similar experiences to me with negative side effects?

I recently moved to the USA and have gained 30 lbs over the past couple of years (currently 207 lbs). The weight gain has really affected my confidence and mental health, and I also have PCOS. I’m planning to start strength training and lifestyle changes, and I’m looking into Wegovy/GLP-1 medications (pills) to support my weight loss journey.
I’m new to the US healthcare system and have my first primary care appointment next month.
Should I bring up Wegovy directly with my PCP?
Can PCPs prescribe it or do they usually refer you to a specialist?
Should I check insurance coverage before or after getting a prescription?
Would appreciate any advice from others who’ve gone through this process. Thank you!

PCOS & Semaglutide

I’ve been struggling with PCOS for a couple of years now. I was still seeing a pediatrician when I was diagnosed and she recommended going on Birth control (the pill) in order to help with the PCOS. I gained 30 pounds in 3 months. I was super active during this time. I was playing competitive softball and was practicing everyday and still gained all of that weight. After that I stopped taking the pill.

I had to do extreme diets and workouts on top of my practices to lose SOME of the weight. I was finally feeling confident again but I would go months without my period and then it would be really bad when I got. Then I started getting it every two weeks, also with bad symptoms. I went to the doctor ( not a pediatrician this time) and she also recommended going on birth control. This time she recommended the implant. I’ve gained back the weight I lost and then some. I eat clean and workout 5-6 times a week. Nothing worked. I am the heaviest I’ve been and I’m feeling helpless

In a desperate attempt to feel confident in my own skin I started a GLP-1 (semaglutide). She also said that this has helped a lot of women who struggle with PCOS. I have been on it for about 4 months and have not lost any weight. I started out on a small dose and have gradually moved up but still have not lost any weight. One of the nurses who swears by it, says that he didn’t start losing weight until the 4 month mark. My problem is that I am a full time college student who is paying for tuition all by myself. I voiced my concerns to them about not seeing any results but still have to pay so much. They assured me that it is going to take time but to not give up yet. It has helped me get my period regularly which was the main goal but I was looking forward to the weight loss as a bonus.

Has anyone tried using a GLP-1? How fast did you see results/ what did you do to help see results? Or does anyone have any tips on how to successfully lose the weight and keep it off?

​tldr: I lost 47 lbs on Zepbound but suffered from severe acid reflux that forced me to sleep sitting up and stop eating by 2 pm. After a break showed me how much more energy I had and how much better I could train without the medication, I decided to quit to protect my health. I am switching to metformin and looking for advice on handling the transition and the fear of weight regain

I’m looking for some insight or similar experiences because I’m feeling a bit lost in my journey right now. I am 5'1" and started Zepbound in October 2024 when I was 185 lbs. My endocrinologist had been suggesting it for over a year, but I resisted until I realized that even with consistent dieting and exercise, the scale just wasn't moving. By December 2025, I had dropped to 138 lbs, eventually reaching a 7.5 mg dose.

​However, the side effects were always a struggle for me. Every time I increased my dosage, I dealt with weeks of GI issues, but the acid reflux was the hardest part. It became so severe that I had to stop eating entirely by 2 pm and spent most nights sleeping sitting up just to manage the pain. While the weight loss was a success, I have to admit a lot of it was because my calories were so heavily restricted by the side effects.

​Earlier this year, I had to take an eight-week break due to insurance coverage updates. During that time, which included some travel, my weight went up to the 148 to 150 lbs range because I was simply eating more. The surprising part was how much better I felt. I could finally sleep horizontally again without reflux, and my energy levels improved so much that I was lifting heavier and working out better than I had in a long time.

​When I tried to restart at 5 mg, and even when I dropped down to 2.5 mg, the acid reflux returned even worse than before. I started waking up with a sore throat that wouldn't clear up for hours. At that point, I decided to prioritize my health and asked my doctor to stop the Zepbound. I am worried about the long-term damage to my throat and teeth, so we are switching back to metformin, which I struggled to take consistently in the past. I am definitely concerned about gaining the weight back, but I am also excited to feel like myself again and move without pain. I would love to hear from anyone who has transitioned away from these shots due to side effects or managed to maintain their progress while switching back to other treatments.

Hi there. Initially I was very against GLP1’s unless you’re a diabetic. Lately, I’ve been seriously considering it. I’m a 30 year old woman with PCOS, diagnosed when I was 19, and always struggled with weight issues. My highest weight was 197 pounds and was able to successfully lower it to as low as 150 on my own naturally via intermittent fasting. Despite still being young, the “older” I get, I can tell my body metabolism is slowing down more though. I am currently 168 pounds and can’t seem to really drop below 165 now. I calorie / nutrition count, eat 100-120g of protein a day, and dont exceed 1500 calories but my body hates me I feel like. I’d say, 1x/week I allow myself a special treat so maybe one day per week is more like 2500 calories, which I know is a lot more but prevents me from binge eating. I also weight lift and am a nurse and on my feet all day. I workout minimum of 4 days per week, if it’s ever only 3- it’s a bad week for me. Sometimes I even do 5-6 days during the summer for hiking. I am extremely active. I also get chronic migraines and read GLP-1’s help with this as well.

One of my worries is my sister is on one and after 1 drink she had cyclic vomiting and was hospitalized for a few days due to this. - from one drink… i wanted to see people’s experience with this. A worry of mine is if I’m on it, it works- if i get off it, won’t i just gain it all back again? So maybe more so of a life time drug for me?

I feel I’m doing all the right things but need the little extra help . I’d really like to be at 150-155 pounds with muscle

(I am 5’7)

Took my first jab yesterday but haven’t felt anything till now. No appetite suppression, nausea, abdominal discomfort, etc. when do the effects start kicking in?

I've been considering injections lately. I was diagnosed with pcos last year after years of thinking I had it. I've always been on the curvier side, especially compared to my sister, so my body dysmorphia is quite bad.

But I'm just fed up of holding my weight all the time. Both my mother and her sister became type 2 diabetic due to their pcos, so I'm afraid of this happening to me as well.

I can get any kind via my job with a discount, so have seriously been thinking about it.

Anyone with experience of Wegovy, how was it? Have you managed to come off and keep weight off with lifestyle changes? Any health risks you were warned about? I never take any other medication, except from the combined pill when I was younger to help with my periods. So I'm terrified of the risks plus the needles >.<

Is anyone on Mounjaro and Metformin?

I took my first dose of MJ yesterday and had such a weird moment of tingling hands and face and a cold sweat later at night. I ate normally all day but had some chocolate when this happened and felt better afterwards and started to feel the same way this afternoon. Had something sweet and now feel a bit better. I was wondering if maybe the metformin and mounjaro together are causing my blood sugar to drop?

Has anyone else experienced this?