>The main villain is William Metzger, the director of the Department of Damage Control, played by Tramell Tillman.
>Sadie Sink is Jean Grey. She wants revenge on Metzger for her sister’s death and has been bodyjacking people to do her bidding.
>Opening montage features Spider-Man fighting several supervillains like Scorpion, Boomerang, Tarantula and Ramrod, who all work for Tombstone.
>Peter is still pining for MJ and Ned, and has been spending most of his time fighting crime to avoid dealing with his shitty life, until his powers begin mutating.
>Jean bodyjacks Scorpion to attack a DODC convoy. Spider-Man stops him and he is arrested. Spider-Man goes on a “predator mode” during the fight and violently wrecks Scorpion, which scares him.
>Peter runs into Ned at the coffee shop in which they used to hang out, and finds out MJ and Ned have moved back to New York after graduating MIT.
>Peter follows Ned and crashes his and MJ’s housewarming party claiming to be their neighbor Maynard, where he finds out MJ has a new boyfriend.
>MJ and Ned remember Spider-Man saved them several times. Ned has developed a Spider-Tracker in hopes of locating him and thanking him.
>Peter returns home, collapses and awakens the next day in a web cocoon from which he emerges with organic webbing and enhanced senses.
>Peter asks Bruce Banner, who is teaching at Empire State University, for help, and Banner develops a microchip based on his own Hulk-inhibiting bracelet to suppress Peter’s mutation.
>Peter is tipped off by Detective Jean DeWolff, his friend in the NYPD, that Tombstone has hired The Hand to intercept the DODC convoy transporting Scorpion to prison and rescue him.
>DeWolff also tips off Punisher, who attacks the convoy to kill Scorpion while Spider-Man holds off The Hand. Spider-Man fends off both.
>Jean bodyjacks an old lady to attack the convoy in a stolen armored car. Spider-Man stops the armored car, but Jean escapes.
>Spider-Man is immune to Jean’s telepathy, and Metzger manipulates him into helping them by claiming Jean is a dangerous criminal.
>Jean threatens Spider-Man to get out of her way. Spider-Man finds out she plans to bodyjack the Hulk to destroy the DODC.
>Spider-Man chases Jean as she body-hops, but his mutation gets in his way. Jean threatens MJ.
>Spider-Man convinces MJ to come with him and asks Punisher to protect her while he deals with Jean, though MJ later convinces Punisher to help Spider-Man.
>Spider-Man and Punisher fight Jean and the Hulk at the DODC offices. Jean loses control, and Savage Hulk comes out and begins destroying everything.
>Spider-Man uses Shocker’s gauntlet and manages to knock out the Hulk and change him back into Banner.
>Metzger arrives and captures Jean and Banner. Spider-Man finds out Metzger has tortured Jean until she escaped and began targeting him. Spider-Man gets shot.
>Punisher takes Spider-Man to the hospital, where Claire Temple operates on him. The doctors choose not to unmask him.
>Spider-Man is in bad shape, and removes the microchip, embracing his new powers, so he can heal faster and go rescue Jean and Banner.
>Spider-Man visits Yelena Belova in a bathhouse to get information. She forces him to strip down to his underwear and mask before helping him.
>Peter retrofits Ned’s Spider-Tracker app to locate the DODC’s secret prison where Metzger is keeping Jean and Banner.
>Spider-Man and Punisher attack the DODC prison and fight The Hand, whom Metzger has employed to help them. They free Jean and Banner, and Jean has an opportunity to kill Metzger, but Spider-Man convinces her not to.
>Metzger faces criminal charges for his actions. Jean offers to restore MJ and Ned’s memories, but Peter ultimately declines, and Jean leaves to find others like her. Spider-Man and Punisher then team up to take out Tombstone.
>Post-credits scene is Ned’s Spider-Tracker app revealing Spider-Man has vanished from the Earth.