I have been on a GLP1 (tirzepatide) since March 2026. I have titrated up every month and am currently on 10mg, today is shot day and I’m deciding if I am going up to 12.5mg or not. I have been overweight my entire life, but bc I have also basically been on a diet my entire life and I enjoy walking/running, I have been able to avoid gaining as much weight as I easily could. My highest weight was 220 lbs as a 5’8 woman, I got down to around 160 a few years ago through extreme dieting but my “normal” weight is mid 170s, although the last 3 years I have gone between 155 and 185 (155 was bc I absolutely starved myself for 5 weeks bc of family stuff and I wasn’t eating anything). I am currently at 174. When I started tirz in March I was at 182. So I have lost a grand total of 8 lbs in 4 months, although I have basically been around this weight for 7 weeks. I am beyond frustrated with my body. I definitely have appetite suppression and at this point I don’t really have any GI symptoms anymore (at least more so than usual, since I have IBS). I don’t think tirz is not working, I think it is more my body. I just can’t figure out what it needs to lose weight. When I’m in a major calorie deficit, I don’t lose weight. When I track calories and eat what I think I should be, I don’t lose weight. When I eat more than what I think I should be eating, I sometimes see a small change in the scale so I think I am not eating enough, so I eat a little more daily than what I want and then guess what, I gain weight. I walk every day 2-5 miles (bc of my dog, so I never miss a day). My food intake is what would be considered a “diet” to other people – no sweets or very limited/infrequent, small breakfast if anything, light lunch, no snacking, healthy dinner. I see other people eating a sandwich every day for lunch and think “my god if I had a sandwich every day for one meal plus other stuff in a day, I would be a million pounds”.
I am desperate for advice. People will say I am not overweight enough to be on a GLP bc I am not “fat enough”. I have an apron belly and haven’t been able to wear pants my entire life bc all my fat is stored in my stomach and I’m so sick of it. I gain weight so easily. I gained 25 lbs in 5 weeks last fall when I said f it I am done depriving myself (I was still only eating what I think is a normal diet for other people and I was still working out). I tried to lose it for 4 months but after having not lost one pound that’s when I got on a GLP. I want to get to 150 (so 25 lbs down) and I really don’t know what I am doing wrong. I eat right, I do cardio, I am on a high dose of GLP and still the scale stays the same or goes up lately. I have been to a dietician. I have done intermittent fasting. I have done 5 small meal/snacks and a normal meal a day. I have starved myself. Nothing works. I was diagnosed with Hashimotos in Spring of 2025 and have been on levothyroxine since then with stable levels until 2 weeks ago. My TSH was high so my dosage was bumped up. But I just need some advice or tips or criticism on what I am doing wrong and what I should be doing differently. Or is my body just effed bc of my thyroid issues? Does your body have a weight it wants to stay at naturally and nothing you do will change that?

I want to lose a bit of weight so I started exercising and reduced my calorie intake (not by an extreme amount, just by about 500). I'm just doing low impact workouts maybe 4 times a week and walking more. After almost 2 weeks of this I suddenly had a huge flare, which started 3 days ago and still hasn't gone away. My entire body hurts like I've been run over by a bus and it's not "exercise" pain -- because it's the same aches and pains I get when I have a really bad flare. I also don't know if it's my hashis or endometriosis but I have felt TAKEN out for 3 days. I have also been incredibly fatigued and the last couple of nights I've slept for 10 hours and still feel tired.

Is this normal? Does anyone else get this?

Just wanting to share a win. 2 months ago got a 38 TSH after being very slack. Got super focused on taking my meds; 5.30 am well before coffee and breakfast. Also started Glp1.

Got blood result’s today and 5!!! FT3 and FT4 also in range. Feeling good!!

Hello everyone! Friday morning I’m going to request a full thyroid panel, and wanted to know if you guys have any advice for me prior to testing. I haven’t been diagnosed for hashi but I am curious if that’s what I have! I stopped taking my multi vitamins a month ago. I am on a GLP 1, and plan on taking it after my test. Is there anything I need to ask for or prepare for before testing?

Hello friends, I am a 26-year-old woman who was just recently diagnosed with Hashimoto’s.

I feel absolutely exhausted all the time, have bad brain fog, and memory problems. It’s essentially disabling me, and I can’t hold down a job like this.

Frustratingly, my hormones have all come back normal. My TSH, T4, and free T3 are normal. But my antibodies are quite high.

I really want to ask my primary care physician if I can go on a trial of thyroid medication. But I’m worried that she’s going to say no, because my hormones are normal. That being said, I’ve heard from many people that hormones can be totally normal and you can still be in a flare.

I was wondering if anybody else has been in the situation and got approved for medication, and what your experience has been.

Thank you so much for your time <3

I’m not overweight, but over the last few years I’ve slowly gained weight that I just can’t lose. More than that, I don’t feel like myself anymore. I’m constantly puffy, feel inflamed, and still have symptoms even when my thyroid labs are “normal.”

At this point, I feel like I’ve exhausted so many options.
I’ve worked with multiple endocrinologists, functional medicine doctors, and other physicians. I’ve tried different thyroid medications, supplements, and just about every lifestyle change imaginable (gluten-free, dairy-free, alcohol-free, caffeine-free, etc.), but nothing has made a meaningful difference.

I’m starting to wonder if a GLP-1 is worth discussing with my doctor. Has anyone had success with a GLP-1 helping with inflammation and overall quality of life — not just weight loss? If you weren’t overweight, were you still able to get one prescribed?

I’d love to hear any experiences, positive or negative. Thanks!

EDIT: I am NYC based and looking for a good endocrinologist to discuss this with. Please DM me if you’ve had a good experience with yours. Willing to travel for the right doc!

I have been suffering with fatigue and depression for the last 12 years. My T3 levels have always hovered around 2.6-2.8 pg/ml, while TSH was at 2-2.5. Can this explain my low energy and weight loss resistance?

I’m seeing a lot of TikTok grifters argue that weight won’t budge until T3 is 3.6-4.2 pg/ml. I am also seeing a lot of people selling a “natural” approach to “reversing” Hashimoto’s, which just makes me extremely angry. I have tried every recommended supplement and lifestyle modification possible, but my thyroid still destroyed itself…

I've heard varying answers, but my face wasn't this puffy before and I have hair thinning.

I lowered my antibodies about 72% in the last year and a half. So current number is 81. If I keep going with all the things I’m doing, it’s got to lower more, right? What’s considered remission? I’ve also seen posts here saying that remission isn’t a thing? Also, planning to get pregnant soon and have heard mixed things about it helping and it making hashis worse. Would love to hear others experiences.

My partner and I have been more serious considering having a baby in the next few years. I am extremely reluctant because of my hashimotos. I haven't met another woman yet who has it while they were pregnant. I know that being pregnant while "normal" can already suck ass, but I want to know how it went for those of y'all who have hashi.

How did it go? How did you navigate it? Biggest challenges? Any advice or recommendations?

And folks who are partners to someone who had a baby, feel free to share some insight too.

Been one heck of last 1.5 years to figure out what has been happening.

First presented with unbelievable cold fingers and hands, on the verge of being painful. Also digestion issues, depressed, and higher anxiety levels. Lost interest in everyday things, and tired all the time. Doctor ran the basic thyroid tests (not TPO) and found that my TSH was high and T4 and other numbers were within range. Started me on the lowest dose of levo, tested again in 6 weeks...TSH went up. Increase dosage, TSH came down.....rinse an repeat increase dosage every 6 weeks to 125mcg.

Now we are here, tested last week for TSH and it went back up. About every other test my TSH rebounded. This last test/follow up my doctor ordered a TPO test, which I was going to ask about after this last test result if he did not suggest getting it done. With all the tests and dosage increases I have felt better and all my numbers keep getting better or not move, so we were both thinking success.

Got the TPO test results and I laughed like I was going crazy. Result came back with a score of 2359. Normal range for the lab test is listed at 0 to 9. I pulled up all my numbers from all the previous tests and did some quick research and with just the TPO test I was like yeah I have Hashimoto's even before I got the official diagnosis from my doctor.

Right now keeping me at the same dosage of levo and testing again in 6 months. I am going to guess that my TSH will be either drop in to normal or still be a tad high as it likes to rollercoaster.

I feel a ton better through the the titration of levo to my current dosage so I know that the meds were working, but the mystery was why my TSH kept on rollercoastering. The TPO test solved that mystery.

This also explains why my Garmin for body battery charge was spikey and my HRV is so slow. Body is attacking itself so it is always in the fight/flight conflict.

Just need to find some ways to manage stress better and see if change of diet will help with any of this. It has been a whirlwind adventure for sure. Just happy to have some concrete answers.

Hey y’all, my endo said my levels are perfect aside from my antibodies (couldn’t find on the page anywhere) and my b12 is too low but looking at this my b12 levels look ok, does anyone know why she’d say that?

I usually love my endocrinologist, I first went to her in 2023 and she on the spot first appointment diagnosed me with PCOS (now PMOS) and Hashimotos, which I’d never heard of. She did some blood work and everything and we started taking care of it. She knows I hate medication and she prefers as little medication as possible so she helped me with figuring out what worked for me without it. I stopped going for a while just because of money and feeling overwhelmed with the healthcare system here in the U.S.

Back in January-February I started having a lot of issues (couldn’t stand for too long without feeling I was going to pass out, getting dizzy and shortness of breath standing and even going from my bedroom to the kitchen, completely exhausted), I don’t know if it was a hashies flare up or what. I did bloodwork in February during all that and it was apparently perfect (frustrating). I went in for an appointment in April, which the issues had already calmed down, still a lot of the same but not as intense, the PA, so not my doctor, told me it was just anxiety and gave me Xanax… even tho I told her I’d been diagnosed since I was 15… and this isn’t anxiety. Needless to say I was really upset leaving my appointment I waited multiple months for so I scheduled with my doctor specifically and just got in yesterday, July 21st. She had me do some bloodwork last week, perfect aside from my vitamin b being too low and two different antibodies being wayyyy too high, but that’s fairly normal for people with multiple autoimmune disorders. Usually my doctor will talk me through everything and educate me as she goes. She didn’t.
I felt very rushed and she kept talking to her assistant (I think?) and saying stuff like “the thyroid is dying” “it used to be failing then regulated itself see here?” But wouldn’t say any of that stuff to me, when I asked what was wrong she would say “everything’s fine” 🤨 ok??? When she did finally talk to me we talked about my last appointment with the PA and how poorly it went and she listened to my symptoms and says she wants to do an adrenal or cortisol test? Idk they’re going to draw my blood, inject me with something and then draw it again 2 times, 30 and 60 minutes later. She said if my cortisol is low I have to start a medication.
I decided to bring up that I have Bipolar cause I figure we should be careful for medications that can interact with it, she goes “way I see it, there’s two rooms, one with normal people and one with people with bipolar, the one with normal people would be empty because everyone has bipolar”
… that’s not how that works. I felt incredibly dismissed an frustrated and confused.
So I felt rushed and dismissed and as I’m walking out they pull me for a test that I wasn’t aware I was getting, something for blood flow I believe. It wasn’t a huge deal but irritating that they didn’t mention it to me before.
I go to schedule my follow up and my test for next week, they also want me to come back for a bone density and thyroid screening… again nobody told me!
It’s just irritating feeling uncared for by a doctor I used to love and trust so much. Luckily I had a great appointment with a nutritionist after and she made my day better but idk. Just needed to rant. May look for a new endo 😣

Is anyone else experiencing this nothing is working for my weight-loss I’ve gained weight on glp but I do feel it helps me with eating one plate instead of 2 but I can still eat I have high TPO antibodies but tsh still normal Dr won’t prescribe me anything because of that I’m a 36 y/o female

Does this mean I'm in remission?? Do I need to do another test?

Hey y’all. I’m 30F with Hashimoto and another mysterious autoimmunity disease where I keep developing food sensitivities out of the blue with loads of inflammation, fatigue, joint pain… the whole thing. I’ve been hearing about micro-dosing GLP1 and wanted to hear y’all experience for anyone who’s taking it.

I barely can keep my weight/muscles on with all these sensitivities so I’m not interested in these medications for weight loss.

So I was diagnosed with Hashimotos last August, but had no active symptoms. In January, I had more bloodwork done, and was diagnosed with subclinical hyperthyroidism, and have never had any symptoms. My T3 snd T4 have stayed within normal ranges consistently since then, despite my TSH being almost undetectable (<0.1-0.2). But I was also told this is known as Hashitoxicosis, and it generally only lasts a month or 2 before transitioning to hypothyroid. Had anyone experienced this stage long term? Ive had it for 7+ months.

From all my research it sounds like I need to keep testing every couple months to make sure my levels don't change or I start to develop active symptoms. I am going to be looking for a specialist as I just moved to a new city, but wondering if anyone in here has been in a similar situation. My last doctor was less than helpful and not very knowledgeable. I've never been prescribed medication for thyroid and I'm otherwise healthy, 37F.

Or if anyone in the Greater Seattle area (Pierce County) knows of a good specialist, I'm open to suggestions.

Hello!
I’m in my 30s have been on levothyroxine for over a decade and suffering with varying symptoms.
I take 150mcg and then 125mcg levothyroxine alternating days.

A few months ago I felt pretty sluggish and very tired so I decided to look carefully at my medication compliance so I now wake up immediately take my medication with water and wait 30-60mins before having any breakfast/coffee

I have had my bloods checked recently as I don’t feel “right”, my TSH is in “normal range” it doesn’t say a number online, but my Doctor said it’s normal.
My T3 = 4.5 (normal range 3.5-6.5)
My free T4 = 24.4 (normal range 11.5-22.7)

My doctor phoned today said that the T4 was abnormally high, but as the TSH was normal to continue taking my current dose and recheck in 6weeks.

I feel mild eye aches, I feel a bit strange in my head (hard to explain) but not like I am going to collapse but similar to what fainting symptoms feel like.

I don’t have any of the common hyperthyroid symptoms.

I also don’t take any other medications, I am currently breastfeeding. I am overweight.

What would you do?
I am worried I am mildly hyperthyroid and do not want to continue my dose if it’s damaging my health, opinions and advice welcome !🙏

I take my levo at night, usually around 2 am when I’m going to bed because I like my coffee right when I get up. Occasionally I’ll have something small like a one inch piece of chocolate or a couple peanuts or something late at night (not a real snack, just something small). It might be past 11 pm at that point.

How important is it to have a totally empty stomach? On those days when I want that small bite I’ve considered not taking the meds and hoping I wake up in the middle of the night, then worrying I won’t so just take it anyway around 2 or 2:30 am when I’m going to bed.

I know two weeks isnt long, but I was expecting to feel amazing and I have no difference. I am also seed oil and refined sugar free for the same amount of time. No difference. I just started my meds 9 days ago. Not much improvement. When did everyone start to notice a positive difference with meds,diet, or both? I am taking NP thyroid

I’m in the U.K.

For years my TPO antibodies were over 500. My mum is coeliac, I carry the gene but biopsy and bloods were routinely negative. I was convinced it was gluten causing my antibody levels to rise, but elimination didn’t help and the numbers didn’t change.

After pregnancy and thyroiditis I noticed every time I had an iced latte my throat would feel swollen and sore. Decided to switch to oat milk, my day to day diet is generally dairy free except for coffee so it was an easy switch.

Had repeat labs done this week and after eight months of avoiding dairy my TPO levels have dropped to just 50. I’ve not changed anything else and am completely floored.