r/Hematology Nov 30 '25

Looking for survivors with MECOM-rearranged / complex karyotype AML (monosomy 5 & 7, persistent disease after 2 stem cell transplants). Please help me find them.

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24 Upvotes

Hi everyone,

I’m reaching out because my sister is fighting for her life, and we’ve reached the point where every piece of information, every connection, and every survivor story might make a real difference.

My sister is 22 and has a very rare, extremely high-risk form of acute myeloid leukemia. Her cytogenetics include:

  • MECOM (3q26/21) involvement
  • Monosomy 5 and 7 (and also monosomy 1)
  • Complex karyotype
  • NPM1-, FLT3-

She relapsed early after her first allogeneic stem cell transplant (unrelated donor, Jan 2025). She then underwent a second allo transplant using my stem cells.
Despite everything, she still has 12–14% blasts, and she’s also fighting a disseminated fungal infection (Mucor + Aspergillus). Immunosuppression is being tapered to try to induce graft-versus-leukemia. She’s in a very fragile and dangerous situation.

I know that her subtype is one of the toughest in AML. But I also know there are rare survivors out there — people with MECOM-rearranged AML, inv(3)/t(3;3) AML, and those with monosomy 5/7 + complex karyotype who managed to beat the odds. Even a handful of these cases exist, and I’m trying to find them.

I’m asking for help with two things:

  1. If you or someone in your family survived AML with similar genetics (MECOM-rearranged, inv(3)/t(3;3), monosomy 7/5, complex karyotype), I would be incredibly grateful to speak to you. I want to understand what treatments worked, which centers helped, and what gave you a fighting chance.
  2. Please help share this post — in leukemia groups, Facebook communities, Discord servers, anywhere. This cancer subtype is so rare that the only way to find survivors is through human networks.

I’m not looking for miracle cures. I just want to learn from people who succeeded against similar odds. Even one message from someone who has been through this could help me point her doctors toward something they haven’t tried yet.

If you know anyone who might be connected to cases like this, please forward this post to them.
If you’re comfortable reaching out privately, please message me directly.

Thank you to everyone reading this — even if you can’t help directly, sharing this could genuinely save her life.


r/Hematology Apr 26 '25

Which Hematology Books Would You Recommend?

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18 Upvotes

Hello everybody I am currently a resident in medical biology, working in the hematology department. I would like to have your opinion on which books to study. Given the large number of available books, which one would you recommend? Thank you!


r/Hematology 23h ago

Question A BM aspirate slide

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6 Upvotes

It looks beautiful. My supervisor reported it as normal.


r/Hematology 7d ago

Question The role of ferritin in IDA

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24 Upvotes

I have no formal medical education but I’m hoping to get a better understanding of iron deficiency anemia. If iron saturation and hemoglobin are responsive to oral iron supplements, what would cause a decrease in ferritin and an increase in TIBC?

If ferritin decreases while iron increases, could it be indicative of bone marrow dysfunction or more likely gastrointestinal blood loss?

I’m sure this topic is very complex but I’d appreciate any insight or literature recommendations so I can gain a better understanding. Thanks!


r/Hematology 9d ago

Question What type of cell is circled in this blood film?

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13 Upvotes

Is it a blast cell?


r/Hematology 10d ago

Blood Report Tracking - For whole Family

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0 Upvotes

How do you track yours and your whole family members blood reports?

Do you usually have report papers stored in one place or use a platform to store it all in one place?


r/Hematology 12d ago

Interesting Find Name that cell

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21 Upvotes

Although I would love to call this a skipocyte, I'm thinking giant thrombocyte? Cool cell though. 😎


r/Hematology 12d ago

CliniCheck is going to get a huge update! What would you like to see next?

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5 Upvotes

Hey,

Just a quick update to let you know that CliniCheck is still actively under development, and Version 1.5 is on the way! This update will introduce new WBC cell types, along with a few other improvements we will share soon.

In the meantime, what we value the most, is a real feedback that we could use to improve. If you have some time, please check it out: CliniCheck!

If you have some features that you would like to see, as a part of this update, drop them in the comments. We'll do our best to squeeze as many ideas in as we can.

Thanks for all the support!


r/Hematology 13d ago

Que celula é essa?

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11 Upvotes

Me parece que cromatina está mais frouxa, mas não me parece um monócito, talvez linfócito reativo mas essas lobulações...


r/Hematology 13d ago

Saw an angry cell at work today 😡

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28 Upvotes

r/Hematology 13d ago

Question Are these lymphocytes or something else?

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15 Upvotes

I'm having a hard time telling lymphocytes from monocytes here... Any help is appreciated!


r/Hematology 18d ago

Microscopy nerd friend looked at my blood, curious what professionals see.

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51 Upvotes

I'm not after medical adviser despite feeling chronically ill for a while but I'm very curious about what people strictly observe here.


r/Hematology 19d ago

Question Post-donation volume adjustment

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6 Upvotes

(Disclaimer: not a medical question, question about blood donation service methodology for calculating and reporting blood volume.)

I'm in Canada, and the Canadian Blood Services app on my phone lets me track my stats such as hemoglobin, bleed time, and donation volume.

There's always a window after my donations where they drastically overreport the volume. ​​​​I gave on Tuesday this week, Wednesday it reported a number over 550 mL, and now today it's settled back down to ​491 mL.

Can anyone tell me why this is?

Secondary question: it's very slight, but if you graph my donations over time and regress it, there is a very slight upward trend in volume. I'm not worried about it or anything, but I am curious if it's just coincidence or if there might be some kind of mechanical reason for it.

Pic unrelated but required to post. ​

(Tried to post this in r/Blooddonors but got sent here.) ​


r/Hematology 20d ago

The WBC lysis nightmare in liquid biopsy (lytic vs non-lytic preservation)

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2 Upvotes

Hey everyone,

Just wanted to be completely upfront here. I work on the technical team at Norgen Biotek, and one of our scientists (who used to do molecular oncology at the Weizmann Institute) is putting together a presentation on July 16th about liquid biopsy pre-analytics and sample stabilization. I wanted to share the topic here to see if anyone working with cfDNA/cfRNA or NGS assay development is dealing with the same bottlenecks.

If you’ve ever had a massive sequencing run ruined because white blood cells lysed during transport and flooded your sample with background genomic DNA (gDNA), you know how annoying it is. It completely buries your low-copy ctDNA signal.

He is going to be sharing our internal data plots and breaking down the chemical differences between lytic and non-lytic preservation, how device selection impacts downstream NGS library complexity, and how to avoid the "purification paradox" across blood, saliva, and urine.

It's a short 30-minute data-review followed by an open Q&A. No aggressive sales pitches, just a deep dive into the pre-analytical science.

It’s happening on Thursday, July 16th (he’s doing a morning and an afternoon session for different time zones).

Link to register: https://attendee.gotowebinar.com/rt/3049686171133346394?source=Reddit

Curious to hear how other labs are handling ambient transport for cell-free RNA without getting killed by gDNA contamination? What tubes are you guys using?


r/Hematology 24d ago

Sickle cell and Housing research

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1 Upvotes

r/Hematology 26d ago

Question I had 2 people today that had these "chunks" in their blood coming out of their PICC lines, the other one was chunkier whitish... does anyone know? Can't just be cholesterol is it?

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12 Upvotes

r/Hematology 28d ago

Looking for Hematologist/Pathologist for undergraduate thesis certification

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4 Upvotes

r/Hematology 29d ago

Discussion I’ve added draggable cell types to CliniCheck - feedback welcome

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5 Upvotes

Hi everyone!

I wanted to share a quick update on CliniCheck.

Version 1.23 is now available and introduces a new feature: you can freely move cell types around the counting grid and arrange your dashboard exactly the way you prefer. The goal is to give you more flexibility and make the counting experience better suited to your workflow.

I hope you’ll find this update useful.

What would make CliniCheck even more useful for you? If there’s something missing or a feature you’d like to see in a future release, please let me know.


r/Hematology Jun 19 '26

Help a writer out...

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5 Upvotes

Hi everyone!

Starting out by saying I am in no means a medical student, which is why I need your help!

I'm currently writing an end-of-the-world style book, and I want to use real world science and medicine in it.

If you'd be willing, I would LOVE to talk about:

- Hematology

- Blood borne diseases

- Communicable diseases

- Genetic diseases

- Differences/Similarities between blood types and their reactions to certain diseases

I would also love some examples of blank medical files that I can use as inspiration to make my own.

I have lots of questions, but I honestly don't know where to start.

If you know anything that could be helpful - truly, ANYTHING! - Please send it my way, I need as much info as I can get!

Thank you in advance everyone :D


r/Hematology Jun 16 '26

Question Questions for Patients with ITP

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2 Upvotes

Hello! I am a premed student working with a company to improve ITP patient experience, especially in the pharmaceutical industry. So, if any ITP patients are reading this, I would love you to fill out this survey so we can better cater to your individual needs because the best way to properly serve a patient is by... listening to patients!


r/Hematology Jun 12 '26

Please share with mothers you know who may be interested in helping with research on Hemophilia A.

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2 Upvotes

r/Hematology Jun 11 '26

Name the morphology

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11 Upvotes

I know there's a specific name for this RBC morphology ("speckled targets") and between 5 of us here tonight none of us can remember it. Help?


r/Hematology May 30 '26

🧐 ¿Sabías que no todos los glóbulos rojos son iguales? 🩸

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4 Upvotes

r/Hematology May 28 '26

What is this granule in lymphocyte nucleus ?

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13 Upvotes

Normal WBC count
Neutrophils 36 %
Lymphocytes 53 %
Atypical lymp 2 %
Mono 8%
Eo 1%
Baso 0%

Is it chediak higashi granules?


r/Hematology May 26 '26

Question Phlebotomy and homeostasis

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2 Upvotes

Hello, if a body overproduces rbc and you try and reduce count with phlebotomy, won't the body continue to try and reach its own homeostasis (back to elevated rbc)? Or is it generally understood as temporary?